The series is not aiming at doing a general purpose engine, the engine is specific to the game Casey is making. Depending on what game you want to make part of the videos will be partially irrelevant. As soon as you can draw something on the screen, read input, and output sounds you can try to make your own game and refining it after watching other videos.
I would say after the first 50 days you have enough knowledge to make a simple game. The part that is important is to apply what you see in the videos and not just watch them.
If you want to know how to do something in particular (e.g. how to set up OpenGL) you can search using
the episode guide.