I'm not sure I understand your question exactly, but: usually the "safe area" requirements for display are about not having critical information displayed on the border, so that if a TV has overscan, the player won't find themselves unable to read, say, the ammo counter on the HUD, etc. So it's really just about positioning, and doesn't really have anything to do with the actual size you make your game art. You still have to make the game art to fill the full resolution. You just make sure you don't put anything in the outer band - however big it is for the technical requirements, often 10% or 5% of the screen - that is essential to see.
- Casey