PE File Format

I'm currently doing some extensive research and work with the Portable Executable file format. I've noticed several members of the game development community have also done work with and mentioned this format. For example, Mike Acton has a fasm PE demo here, and I also saw a post about corkami's posters in the Handmade Dev forum.

My question is, as a game developer (or otherwise), what work have you done specifically with the PE format and how has learning about the format helped in your game development? Thank you.